Manganese peroxidase
| manganese peroxidase | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| EC number | 1.11.1.13 | ||||||
| CAS number | 114995-15-2 | ||||||
| Databases | |||||||
| IntEnz | IntEnz view | ||||||
| BRENDA | BRENDA entry | ||||||
| ExPASy | NiceZyme view | ||||||
| KEGG | KEGG entry | ||||||
| MetaCyc | metabolic pathway | ||||||
| PRIAM | profile | ||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||
| Gene Ontology | AmiGO / EGO | ||||||
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In enzymology, a manganese peroxidase (EC 1.11.1.13) is an enzyme that catalyzes the chemical reaction
- 2 Mn(II) + 2 H+ + H2O2
2 Mn(III) + 2 H2O
The 3 substrates of this enzyme are Mn(II), H+, and H2O2, whereas its two products are Mn(III) and H2O.
This enzyme belongs to the family of oxidoreductases, to be specific those acting on a peroxide as acceptor (peroxidases). The systematic name of this enzyme class is Mn(II):hydrogen-peroxide oxidoreductase. Other names in common use include peroxidase-M2, and Mn-dependent (NADH-oxidizing) peroxidase. It employs one cofactor, heme. This enzyme needs Ca2+ for activity.
White rot fungi secrete this enzyme to aid lignin degradation.
Structural studies
As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes 1MN1, 1MN2, 1YYD, 1YYG, 1YZP, and 1YZR.
References
- Glenn JK, Akileswaran L, Gold MH (1986). "Mn(II) oxidation is the principal function of the extracellular Mn-peroxidase from Phanerochaete chrysosporium". Arch. Biochem. Biophys. 251 (2): 688–96. doi:10.1016/0003-9861(86)90378-4. PMID 3800395.
- Paszczynski A, Huynh VB, Crawford R (1986). "Comparison of ligninase-I and peroxidase-M2 from the white-rot fungus Phanerochaete chrysosporium". Arch. Biochem. Biophys. 244 (2): 750–65. doi:10.1016/0003-9861(86)90644-2. PMID 3080953.
- Wariishi H, Akileswaran L and Gold MH (1988). "Manganese peroxidase from the basidiomycete Phanerochaete chrysosporium: spectral characterization of the oxidized states and the catalytic cycle". Biochemistry 27 (14): 5365–5370. doi:10.1021/bi00414a061. PMID 3167051.